What is pain sensitization?

-

Pain is a sensation of hurt resulting from the activation of pain pathways by harmful stimuli to lead to tissue damage. Detection of the stimuli is a protective process to help the body prevent injury or to avoid further contact with the stimuli. However in many clinical conditions the pain is no longer protective, but causes harm. The pain in these situations arises spontaneously, can be elicited by normally innocuous stimuli, is exaggerated and prolonged in response to noxious stimuli and spreads beyond the site of injury. This is caused by pain sensitization. There are two types of sensitizations: peripheral sensitization is a reduction in threshold and amplification in the responsiveness of pain receptors. This occurs when the receptors are exposed to inflammatory mediators and damaged tissue. Central sensitization is an enhancement in the function of neurons and circuits in pain pathways. This is caused by increases in membrane excitability and synaptic efficacy as well as to reduced inhibition in central nervous system in response to activity, inflammation, and neural injury. As a result previous non harmful stimuli generate amplified signals. Central sensitization is responsible for many of the temporal, spatial, and threshold changes in pain sensibility in acute and chronic clinical pain settings and exemplifies the fundamental contribution of the central nervous system to the generation of pain hypersensitivity.

Location: Union Ct, Richmond TW9 1AA, UK

Popular posts from this blog

The Connection Between Facial Expression Muscles and Wrinkles: Understanding the Aging Process

-
Introduction: Facial expressions are an integral part of human communication, allowing us to convey a wide range of emotions and connect with others on a deeper level. However, over time, the repeated contraction of facial muscles can contribute to the formation of wrinkles. In this article, we will explore the relationship between facial expression muscles and wrinkles, shedding light on the aging process and providing insights into ways to maintain a youthful appearance. Understanding Facial Expression Muscles: The human face is equipped with a complex network of muscles responsible for producing facial expressions. These muscles are connected to the skin and work in harmony to create various movements, such as smiling, frowning, and raising eyebrows. While these expressions are crucial for non-verbal communication, the repetitive use of facial muscles can lead to the development of wrinkles. The Role of Collagen and Elastin: Collagen and elastin are two essential proteins
Read more

Having foot drop? Tried acupuncture?

-
 Acupuncture helps improving foot drop Foot drop, sometimes called drop foot is a muscular weakness or paralysis that makes it difficult to lift the front part of your foot and toes. This causes the toes to drag along the ground while walking. To avoid dragging the toes, people with foot drop may lift their knee higher than normal. Or they may swing their leg in a wide arc. Foot drop can happen to one foot or both feet at the same time. Foot drop is a symptom rather than a condition. The causes could be muscle disorders, nerve damage in the leg, or brain and/or spinal injury. Muscles disorders including muscular dystrophy, amyotrophic lateral sclerosis and polio cause the muscles to progressively weaken causing foot drop. Some conditions including sports injuries, diabetes, spending long hours sitting cross-legged or squatting, hip or knee replacement surgery, childbirth etc could cause peroneal nerve damage or compressed causing foot drop. Brain or spinal disorders including stroke, m
Read more