A plant microRNA, MIR2911, which is enriched in honeysuckle decoction (HD), was proved previously that it directly targets influenza A viruses (IAV), including H1N1, H5N1, and H7N9 subtypes by binding to their mRNA and blocking protein translation. These microRNAs after being taken can self-assemble into exosomes and go into the circulation and be delivered into target tissues or specific cells, including the liver, lung, spleen, pancreas, and T cells.
A new study indicated that this absorbed MIR2911 directly and sufficiently inhibits SARS-CoV-2 replication which causes Covid-19. The clinical study assessed the antiviral effect of MIR2911 in HD on COVID-19 patients. This study were involved in seventy-five moderate type COVID-19 patients who received routine antiviral therapy (RT) at Nanjing Second Hospital from January 2020 to March 2020. Their result suggest that absorbed plant MIR2911 in HD inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients. HD treatment might greatly help cure infected patients and stop the COVID-19 pandemic.
References
https://www.nature.com/articles/s41421-020-00197-3
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