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Maggie Ju (2014) Current opinion in acupuncture on stroke rehabilitation
The Journal of Chinese Medicine And Acupuncture Volume 21 Issue 2 September 2014 P9
Maggie Ju. (2015) What Part Does Acupuncture Play in IVF?
The Journal of Chinese Medicine And Acupuncture Volume 22 Issue 1 March 2015 P21
Maggie Ju (2020) The Potentiality of COVID-19 Treatment with Chinese Herbal Medicine in the UK
The Journal of Chinese Medicine And Acupuncture Volume 27 Issue 2 November 2020 P9
Monday, 14 October 2019
Sperm DNA fragmentation is related to infertility
DNA damage may exert its effect at different stages of the reproductive procedure, beginning from the pre-implantation development of the embryo to the achievement and sustaining of pregnancy and finally the creation of healthy offspring. An inverse relationship has been reported between the likelihood of achieving pregnancy either by natural intercourse or by application of ART and the presence of high sperm DNA fragmentation levels. Men with abnormal semen parameters have a higher risk of high levels of DNA fragmentation. Men with infertility have increased levels of fragmented sperm DNA and vice versa. Abnormal chromosome rate which triggers DNA fragmentation is higher in poor quality sperm samples. Research has shown that Sperm nuclear DNA fragmentation has been positively correlated with lower fertilization rates in IVF, impaired implantation rates, an increased incidence of abortion and disease in offspring. For example, a study investigated correlation of fertilization rate with sperm DNA fragmentation in A 85 couples undergoing infertility treatment with IVF/ICSI. The result has shown that fertilization rate was inversely correlated with DNA fragmentation. In addition, the slower embryo development and worst morphology on day 6 was correlated with higher sperm DNA fragmentation. There was a negative correlation between DNA fragmentation and the implantation rate. Analysis from a study including 2969 couples has shown that there was a significant increase in miscarriage in patients with high DNA damage compared with those with low DNA damage.
As mentioned above, sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It shows more promise than conventional semen parameters from a diagnostic perspective. Another recent study has shown that it is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases; A study involved in 2,756 couples, 965 pregnancies has also shown that high-level sperm DNA fragmentation has a detrimental effect on outcome of IVF/ICSI, with decreased pregnancy rate and increased miscarriage rate. The analysis by type of procedure (IVF vs. ICSI) indicated that high sperm DNA damage was related to lower pregnancy rates in IVF but not in ICSI cycles, whereas it was associated with higher miscarriage rates in both IVF and ICSI cycles.
Sperm DNA damage is often the result of increased oxidative stress in the male reproductive tract, the potential contribution of antioxidant therapy. Do you know that acupuncture improves sperm quantity and quality? Acupuncture could reduce oxidative damage and is a potential useful therapy to treat sperm DNA damage.
Muriel et al Fertil Steril (2006) 85:371-83
Robinson et al HumRepord (2012) 27:2908-17
Zhao et al Fertil Steril (2014) 102:998-1005
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