Inflammation is present in women’s reproductive system physiology. There is temporary changes reflected inflammation process observed in the ovary during follicular development, ovulation and luteal formation. Immune cells accumulate in the inner lining of the uterus during the secretary phase of the menstrual cycle indicating inflammation involved in the endometrial cycles in the uterus. Recent research found that a special protein which can inhibits immune cell function and has local anti-inflammatory effect prevented immune attack to the embryo and created a local hospitable environment in the uterus in early pregnancy without compromising maternal system immune function. Inflammation plays an important role in implantation as well.
Inflammation is involved in infertility. There are two major types of problems that account for most of women’s infertility: anatomic abnormality and ovulatory problems. Most anatomic abnormalities such as tube blockage that cause infertility are acquired. Infection, inflammation, ischemia and surgical injury may be the causes. Anatomic abnormalities may be asymptomatic or may be presenting pelvic pain, pelvic adhesions and infertility. Inflammation causes tissue damage and distortion. The most significant cause of inflammatory infertility is Chlamydia trachomatis infection that may result in infertility in 10-30% of infertile couples in developed countries. Inflammation causes ovulatory abnormalities. Premature ovarian failure (POF) is a typical example of the relationship between ovulatory infertility and inflammation. The incidence of POF is 1% of women under the age of 40. About 50% of POF cases have attributed to immune problems which are involved in inflammation. Antiovarian antibodies have been found in some of these cases and accumulation of immune cells in ovaries has been noted as well. Women with endometriosis are also responding to inflammation differently from those women without endometriosis. There are increased immune cells and antibodies against inner lining of uterus.
In men, infection and inflammation of the reproductive tract including testes are widely accepted as important factors of male infertility. Inflammation is associated with disruption of testicular function leading to low sperm count and low quality of sperms. Acupuncture improves sperm count and quality of sperms. This is because acupuncture increased blood supply of testicular artery and acupuncture stimulated immune response and reduced inflammation.
Weiss G et al Reprod Sci (2009) 16: 216-229